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Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia. Persistent or chronic immune thrombocytopenias (P/C-ITP) are acquired blood disorders lasting more than 3 months or 1 year, respectively. The pathogenesis...
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The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling Development and stabilization of a vascular plexus requires the coordination of multiple signalling processes. Wnt planar cell polarity (PCP) signalling is...
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Frizzled7 controls vascular permeability throughthe Wnt-canonical pathway and cross-talk with endothelial cell junction complexes AIMS: Vascular permeability is essential for the health of normal tissues and is an important characteristic of many disease states. The...
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Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation Recruitment of mural cells (MCs), namely pericytes and smooth muscle cells (SMCs), is essential to improve the maturation of newly formed vessels. Sonic hedgehog (Shh) has been suggested to...
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Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. OBJECTIVE: The purpose of this study is to further document alteration of signal transduction pathways, more particularly of hedgehog (Hh) signaling, causing impaired ischemic...
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Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis RATIONALE: A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been...
