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Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation Recruitment of mural cells (MCs), namely pericytes and smooth muscle cells (SMCs), is essential to improve the maturation of newly formed vessels. Sonic hedgehog (Shh) has been suggested to...
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Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. OBJECTIVE: The purpose of this study is to further document alteration of signal transduction pathways, more particularly of hedgehog (Hh) signaling, causing impaired ischemic...
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Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis RATIONALE: A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been...
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Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Abstract RATIONALE: Blood vessel growth and patterning have been shown to be regulated by nerve-derived signals. Desert hedgehog (Dhh), one of the Hedgehog family members, is...
