Postnatal control of cerebrovascular maturation by astrocytes
My research background in neuroscience (Bordeaux U., Montreal U.) and cerebrovascular biology (McGill U., Harvard U.) allowed me to bridge the gap between these disciplines, with a solid foundation in anatomical, physiological, biochemical and genetic approaches. I have developed a unique expertise focused on elucidating mechanisms of cerebrovascular plasticity and neurovascular interactions in health and disease. Research goals from the Lacoste lab include investigating: 1) How cerebrovascular networks develop; 2) What mechanisms underlie their plasticity; 3) How vascular integrity and function are altered in neurological conditions; and 4) How targeting cerebrovascular remodeling may offer therapeutic options throughout life. Identifying key cellular and molecular mediators of cerebrovascular health is an essential pre-requisite for developing novel therapeutic strategies.