136 Rue Léo Saignat
33000 Bordeaux
France
Konstantin STARK
http://www.sfb914.med.uni-muenchen.de/index.html
Stasis induced venous thrombosis as an inflammatory disease
Although venous thrombosis is a common disease, the processes initiating clot formation are not well understood. We could show that venous thrombosis shares many similarities to sterile inflammation and this mechanism is essential to trigger activation of the coagulation system in this setting. Using intravital microscopy in a mouse model of reduced venous blood flow we could characterize the recruitment of myeloid leukocytes and platelets to the developing thrombus. The interplay of these cell types is essential to trigger the activation of the coagulation cascade resulting in fibrin formation and vessel occlusion. However, these processes are context dependent and other mechanisms control venous thrombogenesis in the setting of malignancy.